The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population
نویسندگان
چکیده
منابع مشابه
ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption
Genetic variants in ATP-binding cassette (ABC) transporter genes are associated with increased susceptibility to adverse drug reactions. We hypothesized that genetic variant ABC transporters (ABCB1 and ABCC2) may be candidate markers for predicting maculopapular eruption (MPE) induced by antituberculosis therapy. We compared the genotype distributions of single nucleotide polymorphisms and hapl...
متن کاملThe association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a Northern Han Chinese population
BACKGROUND We investigated the association between oxcarbazepine (OXC)-induced maculopapular eruption (MPE) and HLA-B alleles in a northern Han Chinese population, and conducted an analysis of clinical risk factors for OXC-MPE. METHODS Forty-two northern Han Chinese patients who had been treated with OXC in Changchun, China were genotyped. Among them were 14 cases with OXC-induced MPE; the re...
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Estrogen and estrogen receptors (ERs) are known to play important roles in the pathophysiology of osteoarthritis (OA). To investigate ER-alpha gene polymorphisms for its associations with primary knee OA, we conducted a case-control association study in patients with primary knee OA (n = 151) and healthy individuals (n = 397) in the Korean population. Haplotyping analysis was used to determine ...
متن کاملMaculopapular eruption and fever due to lamotrigine followed by subsiding flare-ups
Case presentation A 27-year-old Caucasian woman treated with LTG 25 mg PO for a depressive episode was hospitalized in our allergy clinic with highly pruritic maculopapular eruption (MPE), affecting her abdomen, chest, back and forearms, which had started 2 days earlier along with fever of 37.5oC. A well-defined red dermographism and tenderness of the skin was observed. She had been prescribed ...
متن کاملMaculopapular eruption secondary to itraconazole.
Adverse cutaneous reactions to itraconazole are known to be quite rare. We report a case of maculopapular reaction caused by itraconazole. On the 7th day of itraconazole therapy for hand onychomycosis, in a 39-year-old woman pruritus occurred with a subsequent morbiliform, symmetric, maculopapular eruption on the upper torso, neck, trunk and pressure-bearing areas. Eruption progressed, becoming...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2015
ISSN: 0013-9580
DOI: 10.1111/epi.13087